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Objective: This study was conducted to evaluate effects of sertraline treatment on symptoms and memory func-tion of posttraumatic stress disorder (PTSD). Methods: Thirty Vietnam veterans were collected for this study, among whom fifteen were PTSD patients and fifteen were combat control subjects. We used Mississippi Scale for Combat-Related PTSD, Combat Exposure Scale (CES), Hamilton Depression Rating Scale (HDRS) and Clinician Administered PTSD Scale (CAPS). Digit Span, Paired Association Learning Test (PALT) and Rey-Osterreith Complex Figure Test (CFT) were assessed for memory function. We evaluated HDRS, CAPS and me?mory function tests at baseline, 2-week and 6-week intervals with each subjects. Results: There were significant differences between PTSD and Non-PTSD veterans in Mississippi Scale for Combat-Related PTSD, CES, HDRS and CAPS. Significant difference was found in memory function tests between PTSD and Non-PTSD veterans. PTSD veterans showed significant improvement in HDRS and CAPS at 2-week and 6-week and in memory function tests at 6-week of sertraline treatment. There was no significant correlation between symptoms and me-mory function. Conclusion: These results suggest that sertraline improve symptoms and memory function of PTSD. There was no significant correlation between PTSD sysmtoms and memory function. (Korean J Psychophannacol 2004; 15(3):346-353)
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